Erythrocyte-driven immunization via biomimicry of their natural antigen-presenting function

la Antigen Mediated Specific Antigen Presenting Function of Articular Chondrocytes

Distribution of Primed T Cells and Antigen-Loaded Antigen Presenting Cells Following Intranasal Immunization in Mice

Priming of T cells is a key event in vaccination, since it bears a decisive influence on the type and magnitude of the immune response. T-cell priming after mucosal immunization via the nasal route was studied by investigating the distribution of antigen-loaded antigen presenting cells (APCs) and primed antigen-specific T cells. Nasal immunization studies were conducted using the model protein ...

Systemic activation of antigen-presenting cells via RNA-loaded nanoparticles

While RNA-pulsed dendritic cell (DC) vaccines have shown promise, the advancement of cellular therapeutics is fraught with developmental challenges. To circumvent the challenges of cellular immunotherapeutics, we developed clinically translatable nanoliposomes that can be combined with tumor-derived RNA to generate personalized tumor RNA-nanoparticles (NPs) with considerable scale-up capacity. ...

Data Driven Techniques for Organizing Scientific Articles Relevant to Biomimicry

Life on earth presents elegant solutions to many of the challenges innovators and entrepreneurs across disciplines face every day. To facilitate innovations inspired by nature, there is an emerging need for systems that bring relevant biological information to this application-oriented market. In this paper, we discuss our approach to assembling a system that uses machine learning techniques to...

Impairment of antigen-presenting cell function by ultraviolet radiation.

UV light irradiation of BALB/c mice was found to result in impairment of antigen-presenting cell function. Adherent trinitrophenyl-derivatized cells from the peritoneal exudate cell population or the spleen of UV-treated donors could not induce hapten-specific delayed hypersensitivity responses in UV-irradiated syngeneic mice, whereas adherent trinitrophenyl-derivatized cells from normal mice w...